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Substantial thalamic norepinephrine transporter occupancy at therapeutic doses has been observed by the tricyclic antidepressant nortriptyline (5070% occupancy), the serotonin-norepinephrine transporter inhibitor venlafaxine (861% occupancy) and duloxetine (3040% occupancy) [174,175,176]

[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Kim JH et al

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